Neuronal vulnerability, pathogenesis, and Parkinson's disease.
Identifieur interne : 000892 ( Main/Exploration ); précédent : 000891; suivant : 000893Neuronal vulnerability, pathogenesis, and Parkinson's disease.
Auteurs : David Sulzer [États-Unis] ; D James SurmeierSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- pathology : Dopaminergic Neurons, Parkinson Disease, Substantia Nigra.
- Animals, Humans.
Abstract
Although there have been significant advances, pathogenesis in Parkinson's disease (PD) is still poorly understood. Potential clues about pathogenesis that have not been systematically pursued are suggested by the restricted pattern of neuronal pathology in the disease. In addition to dopaminergic neurons in the substantia nigra pars compacta (SNc), a significant number of other central and peripheral neuronal populations exhibit Lewy pathology (LP), phenotypic dysregulation, or frank degeneration in PD patients. Drawing on this literature, there appears to be a small number of risk factors contributing to vulnerability. These include autonomous activity, broad action potentials, low intrinsic calcium buffering capacity, poorly myelinated long highly branched axons and terminal fields, and use of a catecholamine neurotransmitter, often with the catecholamine-derived neuromelanin pigment. Of these phenotypic traits, only the physiological ones appear to provide a reachable therapeutic target at present.
DOI: 10.1002/mds.25187
PubMed: 23589357
Affiliations:
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Le document en format XML
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